In situ demonstration of Epstein-Barr virus in intravenous drug abusers with generalized lymphadenopathy.

نویسندگان

  • F Mampaso
  • C Bellas
  • A Molina
  • C Quereda
  • T Bricio
  • L Buzon
چکیده

We have studied by the in situ hybridization method the presence of Epstein-Barr virus (EBV) DNA genome in lymph node tissues from 11 patients with persistent generalized lymphadenopathy. Using a biotinylated EBV DNA probe, we demonstrated EBV nucleic acid in scattered germinal centre cells in eight of the 11 cases. Our results suggest that EBV is not a determinant factor in the pathogenesis of this lymphadenopathy, but support its possible implication in B cell malignant transformation in cases of AIDS-associated lymphoma.

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عنوان ژورنال:
  • Postgraduate medical journal

دوره 68 803  شماره 

صفحات  -

تاریخ انتشار 1992